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BUPROPION SUSTAINED-RELEASE (SMOKING DETERRENT) - ORAL

 

(byou-PRO-pee-on)

 

COMMON BRAND NAME(S): Zyban

 

WARNING: This medication is used as an aid for quitting smoking. It may also be used to treat depression (antidepressant). While antidepressants can provide great benefits, a small percentage of people younger than 25 taking these medications for various psychiatric conditions have had a worsening of depression/other symptoms, including suicidal thoughts/attempts. However, depression itself can sometimes lead to suicidal thoughts/attempts as well, in both children and adults. Therefore, when medications to treat depression/other psychiatric conditions (antidepressants) are used (especially in people younger than 25), the benefits and risks must be discussed with the doctor. Though there are no similar study results for adults, this warning information applies to adults taking these medications as well.

Tell your doctor immediately if you notice new or worsening depression/other psychiatric symptoms, unusual changes in behavior (including possible suicidal thoughts/attempts), or other mental/mood changes (such as new/worsening anxiety, agitation, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Watch for these symptoms especially at a time of dosage change, or when the medicine is being started.

 

USES: This medication is used in combination with a stop-smoking program (e.g., support group, counseling) to help you quit smoking. Bupropion can decrease your nicotine withdrawal symptoms (e.g., irritability, anxiety, restlessness) and your urge to smoke. Quitting smoking decreases your risk of heart and lung disease, as well as cancer.

This medication belongs to a class of medications known as antidepressants. It is not known exactly how bupropion works to reduce smoking urges. It may work by restoring the balance of certain natural chemicals (neurotransmitters) in the brain.

 

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This drug may also be used to treat other mental/mood disorders such as depression and attention deficit hyperactivity disorder (ADHD). It is also used with other mood stabilizers to treat bipolar disorder.

 

HOW TO USE: Read the Medication Guide and Patient Information Leaflet available from your pharmacist before you start taking bupropion and each time you get a refill. Consult your doctor or pharmacist if you have any questions.

Take this medication by mouth, usually twice daily with or without food. If stomach upset occurs, take with food. It is important to take your doses at least 8 hours apart or as directed by your doctor to decrease your risk of seizure.

You may have trouble sleeping when you start taking this drug. Do not take your evening dose too close to bedtime.

Swallow this medication whole. Do not crush, chew, or break the tablets. Doing so can destroy the slow release of the drug and may increase your risk of side effects, including seizures.

Your dosage is based on your medical condition and response to therapy. Your dose may be slowly increased to limit side effects. Do not take more or less medication than prescribed. Do not take more than 150 milligrams in a single dose. Do not take more than 300 milligrams per day. Taking more than the recommended dose of this medication may increase your risk of having a seizure.

It is recommended that you do not try to quit smoking until you have been taking bupropion for 1 week so that the drug can reach a high enough level in your blood. Set a date for quitting, and stop smoking sometime in the second week of taking the drug.

If necessary, this medication may be combined with nicotine patches or gum to help you quit smoking. Ask your doctor for more information. The combination of nicotine and this medication may increase your blood pressure. Your doctor may need to monitor your blood pressure closely. Do not smoke at any time if using any nicotine products with this drug. Too much nicotine can cause serious side effects.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.

Tell your doctor if you are not able to stop smoking after 7 to 12 weeks on this medication.

 

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